abstract：:For the induction of robust humoral and cellular immune responses, a strong rationale exists to use vaccine-adjuvant combinations possessing both immune modulatory and enhanced delivery capabilities. Herein, we evaluated the combination of 2 different adjuvants, a TLR9 agonist, composed of synthetic oligodeoxynucleoti...

journal_title：BioMed research international

authors： McCluskie MJ,Weeratna RD,Evans DM,Makinen S,Drane D,Davis HL

更新日期：2013-01-01 00:00:00

abstract：:The impairment of wound healing in diabetic patients is an important clinical problem affecting millions of patients worldwide. Various clinical and basic science studies show that stem cell therapy, as a regenerative medical therapy, can be a good solution. In this paper, we begin with an introduction of the cellular...

journal_title：BioMed research international

authors： Yang M,Sheng L,Zhang TR,Li Q

更新日期：2013-01-01 00:00:00

abstract：:The aim of this study was to detect the inhibitory action of the early growth response gene-1 DNA enzyme (EDRz) as a carrying agent by liposomes on vascular smooth muscle cell proliferation and intimal hyperplasia. An autogenous vein graft model was established. EDRz was transfected to the graft vein. The vein graft s...

journal_title：BioMed research international

authors： Liu C,Zhang X,Wang S,Cheng M,Liu C,Wang S,Hu X,Zhang Q

更新日期：2013-01-01 00:00:00

abstract：:Integrins are a family of membrane-spanning proteins that are important receptors for cell adhesion to extracellular matrix proteins. They also provide connections between the extracellular environment and intracellular cytoskeletons and are responsible for activation of many intracellular signaling pathways. In vitro...

journal_title：BioMed research international

authors： Zhong Y,Wang J,Luo X

更新日期：2013-01-01 00:00:00

abstract：CONTEXT:The 7th (2009) edition of the AJCC melanoma staging system incorporates tumor (Breslow) thickness, MR, and ulceration in stratifying T1 primary melanomas. Compared to the prior 6th (2001) edition, MR has replaced CL for thin melanomas. OBJECTIVE:We sought to identify and report differences of the classificatio...

journal_title：BioMed research international

authors： Chu VH,Tetzlaff MT,Torres-Cabala CA,Prieto VG,Bassett R Jr,Gershenwald JE,McLemore MS,Ivan D,Wang WL,Ross MI,Curry JL

更新日期：2013-01-01 00:00:00

abstract：:The aging process causes a number of changes in the skin, including oxidative stress and dyschromia. The kojic acid (KA) is iron chelator employed in treatment of skin aging, and inhibits tyrosinase, promotes depigmentation. Nanotechnology-based drug delivery systems, such as liquid crystalline systems (LCSs), can mod...

journal_title：BioMed research international

authors： Gonçalez ML,Corrêa MA,Chorilli M

更新日期：2013-01-01 00:00:00

abstract：:The anaerobic skin commensal Propionibacterium acnes is an underestimated cause of human infections and clinical conditions. Previous studies have suggested a role for the bacterium in lumbar disc herniation and infection. To further investigate this, five biopsy samples were surgically excised from each of 64 patient...

journal_title：BioMed research international

authors： Rollason J,McDowell A,Albert HB,Barnard E,Worthington T,Hilton AC,Vernallis A,Patrick S,Elliott T,Lambert P

更新日期：2013-01-01 00:00:00

abstract：:A large body of evidence has emerged over the past years to show the critical role played by inflammation in the pathogenesis of several diseases including some cardiovascular, neoplastic, and neurodegenerative diseases, previously not considered inflammation-related. The anti-inflammatory action of ω-3 polyunsaturate...

journal_title：BioMed research international

authors： Calviello G,Su HM,Weylandt KH,Fasano E,Serini S,Cittadini A

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:India has one of the highest tuberculosis (TB) burdens globally. However, few studies have focused on TB in young children, a vulnerable population, where lack of early diagnosis results in poor outcomes. METHODS:Young children (≤ 5 years) with suspected TB were prospectively enrolled at a tertiary hospital...

journal_title：BioMed research international

authors： Jain SK,Ordonez A,Kinikar A,Gupte N,Thakar M,Mave V,Jubulis J,Dharmshale S,Desai S,Hatolkar S,Kagal A,Lalvani A,Gupta A,Bharadwaj R

更新日期：2013-01-01 00:00:00

abstract：:Targeting nanoparticles by conjugating various specific ligands has shown potential therapeutic efficacy in nanomedicine. However, poor penetration of antitumor drugs into solid tumors remains a major obstacle. Here, we describe a targeting strategy for antitumor drug delivery by conjugating a crosslinked multilamella...

journal_title：BioMed research international

authors： Liu Y,Ji M,Wong MK,Joo KI,Wang P

更新日期：2013-01-01 00:00:00

abstract：:Candida krusei is osmotolerant yeast used for the production of glycerol. Addition of osmolyte such as NaCl into culture medium can increase the production of glycerol from glucose, but osmolytes may burden the glycerol separation. A coencapsulation method was suggested to create local extracellular hyperosmotic stres...

journal_title：BioMed research international

authors： Chen G,Yao S

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Cancer/testis antigens (CTAs) are ideal targets for cancer immunotherapy in virtue of their restricted expression profile in normal tissues. However, CTA-targeted immunotherapy has been rather disappointing clinical setting for CTAs are downregulated by cytosine-phosphate-guanosine (CpG) methylation in their...

journal_title：BioMed research international

authors： Sun JZ,Gao L,Gao L,Wang W,Du N,Yang J,Wan L,Liu F,Wang LL,Yu L

更新日期：2013-01-01 00:00:00

abstract：:The administration of probiotic bacteria for health benefit has rapidly expanded in recent years, with a global market worth $32.6 billion predicted by 2014. The oral administration of most of the probiotics results in the lack of ability to survive in a high proportion of the harsh conditions of acidity and bile conc...

journal_title：BioMed research international

authors： Solanki HK,Pawar DD,Shah DA,Prajapati VD,Jani GK,Mulla AM,Thakar PM

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:There is a paucity of a biological large animal model of myocardial infarction (MI). We hypothesized that, using autologous-aggregated platelets, we could create an ovine model that was reproducible and more closely mimicked the pathophysiology of MI. METHODS:Mepacrine stained autologous platelets from male ...

journal_title：BioMed research international

authors： Spata T,Bobek D,Whitson BA,Parthasarathy S,Mohler PJ,Higgins RS,Kilic A

更新日期：2013-01-01 00:00:00

abstract：:5-Florouracil (5-FU) is the basic agent used in the treatment of gastric cancer. Capecitabine, a prodrug of 5-FU, displays increased antitumor efficacy compared with 5-FU in the clinic. 5'-Deoxy-5-fluorouracil (5'-DFUR), the metabolite of capecitabine, is converted to 5-FU by the enzyme thymidine phosphorylase (TP), w...

journal_title：BioMed research international

authors： Zhu Y,Xu L,Fan Y,Li C,Zhang Y,Zheng H,Hou K,Qu X,Liu Y

更新日期：2013-01-01 00:00:00

abstract：:Enzymes play important roles in most of the biological processes. Although only a small fraction of residues are directly involved in catalytic reactions, these catalytic residues are the most crucial parts in enzymes. The study of the fundamental and unique features of catalytic residues benefits the understanding of...

journal_title：BioMed research international

authors： Chien YT,Huang SW

更新日期：2013-01-01 00:00:00

abstract：:Since 2001 the Istituto Superiore di Sanità established a quality assurance programme for molecular genetic testing that covers four pathologies: Cystic Fibrosis (CF), Beta Thalassemia (BT), Fragile X Syndrome (FX), and Familial Adenomatous Polyposis Coli (APC). Since 2009 this activity is an institutional activity an...

journal_title：BioMed research international

authors： Censi F,Tosto F,Floridia G,Marra M,Salvatore M,Baffico AM,Grasso M,Melis MA,Pelo E,Radice P,Ravani A,Rosatelli C,Resta N,Russo S,Seia M,Varesco L,Falbo V,Taruscio D

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:To study effects of a one-year multicomponent intervention on perceived environmental barriers in hip fracture patients. DESIGN:Randomized controlled trial of a 12-month home-based rehabilitation aiming to improve mobility and function (ISRCTN53680197); secondary analyses. Subjects. Community-dwelling hip f...

journal_title：BioMed research international

authors： Portegijs E,Rantakokko M,Edgren J,Salpakoski A,Heinonen A,Arkela M,Kallinen M,Rantanen T,Sipilä S

更新日期：2013-01-01 00:00:00

abstract：:It has been reported that diabetes mellitus (DM) was an epidemiologically identified risk factor for development of dengue hemorrhagic fever (DHF)/severe dengue in dengue virus (DENV) affected patients, and T helper 2 (Th2) cytokines such as interleukin-4 (IL-4) and IL-10 each plays an important role in the immunopath...

journal_title：BioMed research international

authors： Lee IK,Hsieh CJ,Chen RF,Yang ZS,Wang L,Chen CM,Liu CF,Huang CH,Lin CY,Chen YH,Yang KD,Liu JW

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:The aim of this report is to study the graft and patient survival in a large cohort of recipients with an analysis of factors that may affect the final outcomes. METHODS:Between March 1976 and March 2008, 1967 consecutive live-donor renal transplants were carried out. Various variables that may have an im...

journal_title：BioMed research international

authors： Ghoneim MA,Bakr MA,Refaie AF,Akl AI,Shokeir AA,Shehab El-Dein AB,Ammar HM,Ismail AM,Sheashaa HA,El-Baz MA

更新日期：2013-01-01 00:00:00

abstract：:Coronary artery disease complicates only 0.01% of all pregnancies. For this reason, more exhaustive data on the management of such cases is lacking. Even guidelines on management of cardiovascular disease in pregnant women are scarce focusing mainly on acute myocardial infarction. This is a complex issue involving tho...

journal_title：BioMed research international

authors： Janion-Sadowska A,Sadowski M,Kurzawski J,Zandecki L,Janion M

更新日期：2013-01-01 00:00:00

abstract：:Mung bean is a hepatoprotective agent in dietary supplements. Fermentation and germination processes are well recognized to enhance the nutritional values especially the concentration of active compounds such as amino acids and GABA of various foods. In this study, antioxidant and hepatoprotective effects of freeze-dr...

journal_title：BioMed research international

authors： Mohd Ali N,Mohd Yusof H,Long K,Yeap SK,Ho WY,Beh BK,Koh SP,Abdullah MP,Alitheen NB

更新日期：2013-01-01 00:00:00

abstract：:A diffusion theory-based, all-physical ab initio protein folding simulation is described and applied. The model is based upon the drift and diffusion of protein substructures relative to one another in the multiple energy fields present. Without templates or statistical inputs, the simulations were run at physiologic ...

journal_title：BioMed research international

authors： Kang Y,Fortmann CM

更新日期：2013-01-01 00:00:00

abstract：:Plant-associated bacteria provide important services to host plants. Environmental factors such as cultivar type and pedoclimatic conditions contribute to shape their diversity. However, whether these environmental factors may influence the plant growth promoting (PGP) potential of the root-associated bacteria is not ...

journal_title：BioMed research international

authors： Marasco R,Rolli E,Fusi M,Cherif A,Abou-Hadid A,El-Bahairy U,Borin S,Sorlini C,Daffonchio D

更新日期：2013-01-01 00:00:00

abstract：:Activity-dependent plasticity as a result of reorganization of neural circuits is a fundamental characteristic of the central nervous system that occurs simultaneously in multiple sites. In this study, we established the effects of subthreshold transcranial magnetic stimulation (TMS) over the primary motor cortex regi...

journal_title：BioMed research international

authors： Hajela N,Mummidisetty CK,Smith AC,Knikou M

更新日期：2013-01-01 00:00:00

abstract：:Metabolomics in maternal-fetal medicine is still an "embryonic" science. However, there is already an increasing interest in metabolome of normal and complicated pregnancies, and neonatal outcomes. Tissues used for metabolomics interrogations of pregnant women, fetuses and newborns are amniotic fluid, blood, plasma, c...

journal_title：BioMed research international

authors： Fanos V,Atzori L,Makarenko K,Melis GB,Ferrazzi E

更新日期：2013-01-01 00:00:00

abstract：:Ricin is a potential biothreat agent with no approved antidote available for ricin poisoning. The aim of this study was to develop potent antibody-based antiricin antidotes. Four strong ricin resistant hybridoma clones secreting antiricin monoclonal antibodies (mAbs) were developed. All four mAbs are bound to conforma...

journal_title：BioMed research international

authors： Hu WG,Yin J,Chau D,Hu CC,Lillico D,Yu J,Negrych LM,Cherwonogrodzky JW

更新日期：2013-01-01 00:00:00

abstract：:Seeking new biomarkers for epithelial ovarian cancer, the fifth most common cause of death from all cancers in women and the leading cause of death from gynaecological malignancies, we performed a meta-analysis of three independent studies and compared the results in regard to clinicopathological parameters. This anal...

journal_title：BioMed research international

authors： Buehler M,Tse B,Leboucq A,Jacob F,Caduff R,Fink D,Goldstein DR,Heinzelmann-Schwarz V

更新日期：2013-01-01 00:00:00

abstract：:Actin is one of the most highly conserved proteins and plays crucial roles in many vital cellular functions. In most eukaryotes, it is encoded by a multigene family. Although the actin gene family has been studied a lot, few investigators focus on the comparison of actin gene family in relative species. Here, the purp...

journal_title：BioMed research international

authors： Zhu L,Zhang Y,Hu Y,Wen T,Wang Q

更新日期：2013-01-01 00:00:00

abstract：:We compared the performances of 3 Multiple Allergen Simultaneous Test (MAST) assays: RIDA Allergy Screen (R-Biopharm, Darmstadt, Germany), MAST Optigen allergy system (Hitachi Chemical Diagnostics, Mountain View, CA), and Polycheck Allergy (Biocheck GmbH, Munster, Germany). Forty sera that tested positive with the RID...

journal_title：BioMed research international

authors： Han M,Shin S,Park H,Park KU,Park MH,Song EY

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:To investigate the anesthetic management in premature infants with retinopathy of prematurity (ROP) treated with intravitreal bevacizumab (IVB) injections. METHODS:A retrospective chart review was performed for the patients with ROP who had IVB injection. Clinical characteristics, demographic variables, ane...

journal_title：BioMed research international

authors： Tokgöz O,Sahin A,Tüfek A,Cınar Y,Güzel A,Ciftçi T,Celik F,Yüksel H

更新日期：2013-01-01 00:00:00

abstract：:An FDA-regulated, prescription medical food (Fosteum; 27 mg natural genistein, 200 IU cholecalciferol, 20 mg citrated zinc bisglycinate (4 mg elemental zinc) per capsule) and an over-the-counter (OTC) supplement (Citracal Plus Bone Density Builder; 27 mg synthetic genistein, 600 mg elemental calcium (calcium citrate),...

journal_title：BioMed research international

authors： Bitto A,Burnett BP,Polito F,Russo S,D'Anna R,Pillai L,Squadrito F,Altavilla D,Levy RM

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship of delivery type, maternal anesthesia, feeding modalities, and first feeding and meconium passage times with early bilirubin levels of healthy infants. METHODS:Cord, 24 hours' and 48 hours' total bilirubin levels were measured in 388 study infants. RESULTS:Infants born with c...

journal_title：BioMed research international

authors： Siyah Bilgin B,Altun Koroglu O,Yalaz M,Karaman S,Kultursay N

更新日期：2013-01-01 00:00:00

abstract：:This study was conducted to determine the effects of feeding oil palm frond silage based diets with added linseed oil (LO) containing high α -linolenic acid (C18:3n-3), namely, high LO (HLO), low LO (LLO), and without LO as the control group (CON) on the fatty acid (FA) composition of subcutaneous adipose tissue and t...

journal_title：BioMed research international

authors： Ebrahimi M,Rajion MA,Goh YM,Sazili AQ,Schonewille JT

更新日期：2013-01-01 00:00:00

abstract：:The effect of Cordyceps militaris (CM) grown on germinated soybeans (GSC) in the inflammatory bowel disease (IBD) model was studied. To demonstrate the preventive effect of GSC extract in a dextran-sodium-sulfate- (DSS-) induced acute colitis mouse model, GSC was administered 2 days before DSS coadministration. GSC si...

journal_title：BioMed research international

authors： Park DK,Park HJ

更新日期：2013-01-01 00:00:00

abstract：:Giardia duodenalis is a small intestinal protozoan parasite of several terrestrial vertebrates. This work aims to assess the genotypic variability of Giardia duodenalis isolates from cattle, sheep and pigs in the Southeast of Brazil, by comparing the standard characterization between glutamate dehydrogenase (gdh) and ...

journal_title：BioMed research international

authors： Fava NM,Soares RM,Scalia LA,Kalapothakis E,Pena IF,Vieira CU,Faria ES,Cunha MJ,Couto TR,Cury MC

更新日期：2013-01-01 00:00:00

abstract：:Unipotent spermatogonial stem cells (SSCs) can be transformed into ESC-like cells that exhibit pluripotency in vitro. However, except for mouse models, their characterization and their origins have remained controversies in other models including humans. This controversy has arisen primarily from the lack of the direc...

journal_title：BioMed research international

authors： Lim JJ,Kim HJ,Kim KS,Hong JY,Lee DR

更新日期：2013-01-01 00:00:00

abstract：:New genomes are being sequenced at an increasingly rapid rate, far outpacing the rate at which manual gene annotation can be performed. Automated genome annotation is thus necessitated by this growth in genome projects; however, full-fledged annotation systems are usually home-grown and customized to a particular geno...

journal_title：BioMed research international

authors： Alioto T,Picardi E,Guigó R,Pesole G

更新日期：2013-01-01 00:00:00

abstract：:During vertebrate development, the lung inaugurates as an endodermal bud from the primitive foregut. Dichotomous subdivision of the bud results in arborizing airways that form the prospective gas exchanging chambers, where a thin blood-gas barrier (BGB) is established. In the mammalian lung, this proceeds through conv...

journal_title：BioMed research international

authors： Makanya A,Anagnostopoulou A,Djonov V

更新日期：2013-01-01 00:00:00

abstract：:POZ/BTB domains are widespread modules detected in a variety of different biological contexts. Here, we report a biophysical characterization of the POZ/BTB of KCTD6, a protein that is involved in the turnover of the muscle small ankyrin-1 isoform 5 and, in combination with KCTD11, in the ubiquitination and degradatio...

journal_title：BioMed research international

authors： Pirone L,Esposito C,Correale S,Graziano G,Di Gaetano S,Vitagliano L,Pedone E

更新日期：2013-01-01 00:00:00